Today, humanity stands at an important juncture of time where genetics determine the approach to treatments and therapies. Drugs are being administered based on susceptibility, and populations at risk of a disease can be helped before the onset. After more than a decade of hard work, by brilliant scientists from all across the world, the human genome was sequenced. And since then the association and genetic susceptibility studies are changing the way we treat our patients and prepare for the inevitable. Ancestrum is such an organization that helps with visiting ourselves from a unique perspective. In addition to becoming aware of our abilities and limitations, we can be vigilant regarding our genetic susceptibilities and control the unwanted exposures that can harm us in many ways.
Ancestry determination is a blessing of modern genetics. And a plethora of techniques can be deployed for achieving results. Sequencing and DNA fingerprinting by restriction enzymes are among the two most utilized processes. In the case of ancestry determination, similarities are checked with the genomes of different ethnicities, and the percentage is validated by associating phenotypes. Mostly small nucleotide polymorphisms and unique sequences are identified and correlated with the target sequences. However, with the flourishment of epigenetics and proteomics as independent disciplines, the processes of phenotypic correlation have become accurate but significantly complicated.
Why take an ancestry DNA test?
In this era of globalization, human being stands out by their unique abilities. And many spend a lifetime looking for the trait that makes them special. An ancestry test helps a human being 7nderstand their roots. And the genetic susceptibility data helps in harnessing untapped strengths and getting an overview of their limitations and capabilities.
An ancestry test involves a study of the whole genome and it is easy to assess the mutations and map the polymorphs in the process. Existing studies can be referred to for the identification of genetic susceptibility and chances of sporadic onset of diseases.
How efficiently a drug can act on physiology depends on the drug susceptibility of a patient. Drugs can be peptides, or small molecules both of which interact with active and functional proteins depending on their microstructures. And the acceptability of these microstructures can be identified without conducting elaborate proteomic structural studies like NMR spectroscopy. Just by assessing the genetic background of proteins key polymorphs and unwanted microstructures can be predicted and a drug can be administered in accordance with that information. And more chances of success can be ensured.
Cancer is often argued to be the next human evolution in the form of immortalization. But we all know the detrimental effects of cancer on mental, financial, and familial domains. A thorough genetic analysis involving the whole genome can identify the mutation load and key polymorphisms that can lead to proteomic deformity and abnormalities in the cell cycle. Thus an individual at risk from cancer due to a plethora of reasons including hereditary mutation accumulation or sporadic exposures can be alerted.
Detection of neurological disorders
Neurological disorders Parkinson’s, ALS, and Fatal Familial insomnia can be detected by a thorough genetic analysis and ancestry tracing. Association studies of polymorphisms and phycological and cognitive test scores can reveal multidimensional disorders like autism and attention deficit hyperactivity disorder.
Detection of unique traits Unique traits are a direct result of inhabiting unique environments. For example, a population living at a high altitude must adapt to the low oxygen levels in the air and a thinner air density. This morphological and genetic uniqueness in terms of gene expression and polymorphisms can be expected. These unique abilities are usually silent and in order to find them out, one must explore the same in a real-world setting. An ancestry DNA test makes sure of the same. Disease like thalassemia or anemia is also a culmination of unique traits which can be detected by an ancestry DNA test.